NAD⁺
Price range: €59,95 through €89,95
NAD+ research compound at ≥99% purity with verified COA. Lyophilized, lab-tested for research use only. EU shipping at NutriPep.eu.
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme involved in hundreds of enzymatic reactions across cellular metabolism. It plays a central role as an electron carrier in cellular respiration and serves as a substrate for a family of enzymes — including sirtuins and PARPs — that regulate gene expression, DNA repair, and stress responses. Its decline with age has made it one of the most intensively researched molecules in the cellular aging and metabolic biology fields.
Research has focused heavily on NAD+’s role in sirtuin activation, particularly SIRT1 and SIRT3, which are NAD+-dependent deacetylases linked to mitochondrial biogenesis, cellular stress resistance, and epigenetic regulation. Studies have explored how NAD+ availability influences these pathways in aging cell models and metabolically active tissues.
NAD+ research also extends to the PARP family of DNA-repair enzymes, which consume NAD+ during the repair of DNA strand breaks. Understanding how NAD+ metabolism intersects with DNA-maintenance pathways is an active area of research in both oncology-related models and aging biology. Researchers also study NAD+ precursors (NMN, NR) in relation to intracellular NAD+ replenishment.
NutriPep supplies NAD+ at ≥99% verified purity with a Certificate of Analysis from independent lab testing. Shipped across the EU in research-grade packaging designed to maintain compound stability.
What researchers should know: in this form, NAD+ is supplied for laboratory research use only. It is not a dietary supplement and is not intended for human consumption or injection in this format. Handle and store in accordance with your institution’s research-compound protocols.
| Dosagem | 1000 MG, 500 MG |
|---|
Relevância em Investigação / Research Relevance
- Investigated in models of cellular energy metabolism and oxidative phosphorylation as a central redox cofactor
- Studied for its role as a rate-limiting substrate in sirtuin-mediated deacetylation and epigenetic regulation
- Examined in research contexts related to PARP-dependent DNA damage repair pathways
- Investigated in models of age-associated NAD⁺ decline and its correlation with mitochondrial function
- Studied for its engagement with CD38 ectoenzyme activity and NAD⁺ consumption pathways
Referências Científicas / Scientific References
- The NAD⁺/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling — Mouchiroud L et al. (Cell, 2013) [DOI: 10.1016/j.cell.2013.06.016]
- Targeting sirtuin 1 to improve metabolism: all you need is NAD⁺? — Cantó C, Auwerx J (Pharmacological Reviews, 2012) [DOI: 10.1124/pr.110.003905]
- NAD⁺ intermediates: The biology and therapeutic potential of NMN and NR — Yoshino J et al. (Cell Metabolism, 2018) [DOI: 10.1016/j.cmet.2017.11.002]
Notas Regulamentares / Regulatory Information
NAD⁺ is an endogenous metabolite and is not a controlled substance. It is not listed on the WADA Prohibited List. It has not been approved as a pharmaceutical by the FDA or EMA. This product is sold exclusively for in-vitro research.
✓ Certificado de Análise Laboratorial (COA)
Lote testado independentemente por terceiros (Janoshik Analytical). Pureza verificada ≥99%.
For research use only. This product is intended exclusively for in-vitro research and laboratory applications. Not approved for human or animal consumption, medical treatment, or therapeutic use.
A Revolução dos Peptídeos na Biologia Celular
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